Quicklink to the 5 Signs for  


Identification of a coagulation disorder.

  • Approximately 1% of the general population has an atypical von Willebrand factor gene.
  • Von Willebrand disease (VWD) and hemophilia
    A & B account for 95–97% of all inherited
    deficiencies of coagulation factors.40
  • Prolonged nosebleeds (more than 10 minutes) are four times more common in female carriers of hemophilia A or B than in non-carriers.12
  • Gynecologists tend to underestimate inherited
    coagulation disorders as an underlying cause of
    menorrhagia.20

Any of the following situations could indicate a coagulation disorder:

  • Hematoma following intramuscular vaccination.
  • Prolonged nosebleeds (epistaxis).
  • Prolonged bleeding (five minutes) after minor
    injuries.
  • Heavy menstrual bleeding (menorrhagia).
When discussing bruising or bleeding with the patient, ask whether he or she has had other symptoms of potential coagulation disorders.

This takes only five minutes – better safe than sorry!




Ask the patient about the 5 Signs

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